The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS)
Self-emulsifying drug delivery systems (SEDDS) consist of isotropic mixtures of oils, surfactants, and solvents that after dispersion emulsify in the aqueous media of the gastrointestinal tract (GIT). SEDDS can deliver hydrophobic drugs, which could enhance their oral bioavailability by protecting t...
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| Format: | Article |
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MDPI AG
2025-02-01
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| Series: | Applied Nano |
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| Online Access: | https://www.mdpi.com/2673-3501/6/1/4 |
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| author | Ana Carolina Carvalho Lopes Serrano Mateus Costa Viana Natalha Vicentina Pinto Eduardo Burgarelli Lages Guilherme Carneiro Gabriel Silva Marques Borges |
| author_facet | Ana Carolina Carvalho Lopes Serrano Mateus Costa Viana Natalha Vicentina Pinto Eduardo Burgarelli Lages Guilherme Carneiro Gabriel Silva Marques Borges |
| author_sort | Ana Carolina Carvalho Lopes Serrano |
| collection | DOAJ |
| description | Self-emulsifying drug delivery systems (SEDDS) consist of isotropic mixtures of oils, surfactants, and solvents that after dispersion emulsify in the aqueous media of the gastrointestinal tract (GIT). SEDDS can deliver hydrophobic drugs, which could enhance their oral bioavailability by protecting them from precipitation and degradation. However, it is important to find the appropriate ratio of their excipients to produce emulsions with the desirable physicochemical characteristics. In this sense, Design of Experiments (DoE) approaches such as central composite design (CCD) and Box–Behnken design (BBD) can reduce the number of experiments necessary to determine the best composition and preparation process of a SEDDS formulation. Therefore, this article aims to discuss drug delivery through SEDDS and how DoE approaches can aid researchers in achieving product quality specifications and optimizing the formulation preparation processes. For this, the most recent and relevant papers were analyzed. This review is expected to guide future research directions for more rational development of SEDDS. |
| format | Article |
| id | doaj-art-6886a3e3a77d49b18ec4a82dcbe23ba9 |
| institution | OA Journals |
| issn | 2673-3501 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Nano |
| spelling | doaj-art-6886a3e3a77d49b18ec4a82dcbe23ba92025-08-20T02:11:12ZengMDPI AGApplied Nano2673-35012025-02-0161410.3390/applnano6010004The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS)Ana Carolina Carvalho Lopes Serrano0Mateus Costa Viana1Natalha Vicentina Pinto2Eduardo Burgarelli Lages3Guilherme Carneiro4Gabriel Silva Marques Borges5Departament of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, BrazilDepartament of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, BrazilDepartament of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, BrazilDepartament of Pharmaceutics, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte 31270-901, BrazilDepartament of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, BrazilDepartament of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, BrazilSelf-emulsifying drug delivery systems (SEDDS) consist of isotropic mixtures of oils, surfactants, and solvents that after dispersion emulsify in the aqueous media of the gastrointestinal tract (GIT). SEDDS can deliver hydrophobic drugs, which could enhance their oral bioavailability by protecting them from precipitation and degradation. However, it is important to find the appropriate ratio of their excipients to produce emulsions with the desirable physicochemical characteristics. In this sense, Design of Experiments (DoE) approaches such as central composite design (CCD) and Box–Behnken design (BBD) can reduce the number of experiments necessary to determine the best composition and preparation process of a SEDDS formulation. Therefore, this article aims to discuss drug delivery through SEDDS and how DoE approaches can aid researchers in achieving product quality specifications and optimizing the formulation preparation processes. For this, the most recent and relevant papers were analyzed. This review is expected to guide future research directions for more rational development of SEDDS.https://www.mdpi.com/2673-3501/6/1/4Design of Experimentsnanomedicineself-emulsifying drug delivery systemsBox–Behnken designcentral composite design |
| spellingShingle | Ana Carolina Carvalho Lopes Serrano Mateus Costa Viana Natalha Vicentina Pinto Eduardo Burgarelli Lages Guilherme Carneiro Gabriel Silva Marques Borges The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS) Applied Nano Design of Experiments nanomedicine self-emulsifying drug delivery systems Box–Behnken design central composite design |
| title | The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS) |
| title_full | The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS) |
| title_fullStr | The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS) |
| title_full_unstemmed | The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS) |
| title_short | The Use of Design of Experiments (DoE) Approaches for the Development of Self-Emulsifying Drug Delivery Systems (SEDDS) |
| title_sort | use of design of experiments doe approaches for the development of self emulsifying drug delivery systems sedds |
| topic | Design of Experiments nanomedicine self-emulsifying drug delivery systems Box–Behnken design central composite design |
| url | https://www.mdpi.com/2673-3501/6/1/4 |
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