Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury

Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury

Abstract Background Radiation-induced jaw injury is one of the most severe complications after radiotherapy for head and neck cancer, which can disrupt patients’ health and quality of life. Although the direct target of inflammation and suppressed bone regeneration activity by ionizing radiation (IR...

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Bibliographic Details
Main Authors: Mengting Zheng, Heng Chen, Zhonglong Liu, Zhouyang Wang, Ting Jiang, Yue He
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Osteonecrosis of the jaw
Lonizing radiation
Dendritic cells
Osteoimmunology
Bone marrow mesenchymal stem cells
Online Access:https://doi.org/10.1186/s13287-025-04508-x
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https://doi.org/10.1186/s13287-025-04508-x

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