Perfusion process with tangential flow filtration for oncolytic VSV-GP production

Perfusion process with tangential flow filtration for oncolytic VSV-GP production

The oncolytic vesicular stomatitis (VSV)-GP virus is a promising therapeutic against cancer. To ensure clinical efficacy, doses with high titers are required, which poses a challenge for the manufacturing process. Perfusion cultivation processes with high cell densities have attracted great interest...

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Bibliographic Details
Main Authors: Orsolya Hamusics, Anja Wittmann, Katrin Hasler, Sabrina Müller, Daniel Birk, Ingo H. Gorr, Alexander Brix, Jorge Soza-Ried
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
vesicular stomatitis virus
oncolytic virus
perfusion
tangential flow filtration
design of experiments
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1588293/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1588293/full

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