ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription

Summary: Single-strand breaks (SSBs) are prevalent DNA lesions implicated in genome instability. The nuclear mitotic apparatus protein (NuMA) has been reported to promote SSB repair (SSBR) and regulate transcription following oxidative stress. ADP-ribosylation, an important post-translational modifi...

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Bibliographic Details
Main Authors: Arwa A. Abugable, Chunyan Liao, Sarah Antar, Matthew Dowson, Sherif F. El-Khamisy
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500508X
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