Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications
The curvature of microchannels significantly influences the direction and amplitude of secondary flow, impacting particle sorting efficiency. Using an inertia-based microchannel model for particle sorting, a detailed flow characterization analysis was done to identify particle sorting and promote st...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tamkang University Press
2025-01-01
|
| Series: | Journal of Applied Science and Engineering |
| Subjects: | |
| Online Access: | http://jase.tku.edu.tw/articles/jase-202508-28-08-0006 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841555680154091520 |
|---|---|
| author | Khola Ikram Syed Maaz Hasan Ch Abdullah M Zulfiqar Emad Uddin Zaib Ali M. Sajid |
| author_facet | Khola Ikram Syed Maaz Hasan Ch Abdullah M Zulfiqar Emad Uddin Zaib Ali M. Sajid |
| author_sort | Khola Ikram |
| collection | DOAJ |
| description | The curvature of microchannels significantly influences the direction and amplitude of secondary flow, impacting particle sorting efficiency. Using an inertia-based microchannel model for particle sorting, a detailed flow characterization analysis was done to identify particle sorting and promote standards methods in the microfluidics field. Bends of various angles have numerous uses in microfluidics, and it is essential to comprehend the flow behavior in these microchannels. This work represents the results of a microchannel analysis with various micro-bend angles. Four microchannel designs were studied with outlet angles of 45◦, 60◦, 90◦, and straight channels. Microchannel was fabricated through SLA 3d printing and laser cutting. To investigate the influence
of flow-related parameters on systems performance, testing was conducted using 10 & 20 µm, 20 & 60 µm, and 40 & 60 µm sized particles and flow rates of 50-250 µL/min to stimulate red and white blood cells. Furthermore, imaging was done using a microscope, and postprocessing was done through MATLAB Image Processing. This study reveals that a detailed investigation of particle sorting is necessary to produce consistent test techniques for microfluidic devices to enhance medical diagnostic field performance and promote advancement in the biomedical industry. |
| format | Article |
| id | doaj-art-683556784e9b4c23b661b76587c963ef |
| institution | Kabale University |
| issn | 2708-9967 2708-9975 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tamkang University Press |
| record_format | Article |
| series | Journal of Applied Science and Engineering |
| spelling | doaj-art-683556784e9b4c23b661b76587c963ef2025-01-08T05:00:16ZengTamkang University PressJournal of Applied Science and Engineering2708-99672708-99752025-01-012881679168710.6180/jase.202508_28(8).0006Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic ApplicationsKhola Ikram0Syed Maaz Hasan1Ch Abdullah2M Zulfiqar3Emad Uddin4Zaib Ali5M. Sajid6Department of Mechanical Engineering, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology (NUST), H-12, Islamabad, PakistanDepartment of Mechanical Engineering, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology (NUST), H-12, Islamabad, PakistanDepartment of Mechanical Engineering, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology (NUST), H-12, Islamabad, PakistanDepartment of Mechanical Engineering, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology (NUST), H-12, Islamabad, PakistanDepartment of Mechanical Engineering, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology (NUST), H-12, Islamabad, PakistanDepartment of Mechanical Engineering, School of Mechanical and Manufacturing Engineering, National University of Sciences and Technology (NUST), H-12, Islamabad, PakistanSchool of Mechanical and Materials Engineering, University College Dublin, Dublin, IrelandThe curvature of microchannels significantly influences the direction and amplitude of secondary flow, impacting particle sorting efficiency. Using an inertia-based microchannel model for particle sorting, a detailed flow characterization analysis was done to identify particle sorting and promote standards methods in the microfluidics field. Bends of various angles have numerous uses in microfluidics, and it is essential to comprehend the flow behavior in these microchannels. This work represents the results of a microchannel analysis with various micro-bend angles. Four microchannel designs were studied with outlet angles of 45◦, 60◦, 90◦, and straight channels. Microchannel was fabricated through SLA 3d printing and laser cutting. To investigate the influence of flow-related parameters on systems performance, testing was conducted using 10 & 20 µm, 20 & 60 µm, and 40 & 60 µm sized particles and flow rates of 50-250 µL/min to stimulate red and white blood cells. Furthermore, imaging was done using a microscope, and postprocessing was done through MATLAB Image Processing. This study reveals that a detailed investigation of particle sorting is necessary to produce consistent test techniques for microfluidic devices to enhance medical diagnostic field performance and promote advancement in the biomedical industry.http://jase.tku.edu.tw/articles/jase-202508-28-08-0006particle sortingmicrofluidicssla printinglaser cuttingmicrochannels |
| spellingShingle | Khola Ikram Syed Maaz Hasan Ch Abdullah M Zulfiqar Emad Uddin Zaib Ali M. Sajid Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications Journal of Applied Science and Engineering particle sorting microfluidics sla printing laser cutting microchannels |
| title | Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications |
| title_full | Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications |
| title_fullStr | Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications |
| title_full_unstemmed | Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications |
| title_short | Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications |
| title_sort | experimental investigation of particle sorting in y channels with variable bifurcation angles for microfluidic applications |
| topic | particle sorting microfluidics sla printing laser cutting microchannels |
| url | http://jase.tku.edu.tw/articles/jase-202508-28-08-0006 |
| work_keys_str_mv | AT kholaikram experimentalinvestigationofparticlesortinginychannelswithvariablebifurcationanglesformicrofluidicapplications AT syedmaazhasan experimentalinvestigationofparticlesortinginychannelswithvariablebifurcationanglesformicrofluidicapplications AT chabdullah experimentalinvestigationofparticlesortinginychannelswithvariablebifurcationanglesformicrofluidicapplications AT mzulfiqar experimentalinvestigationofparticlesortinginychannelswithvariablebifurcationanglesformicrofluidicapplications AT emaduddin experimentalinvestigationofparticlesortinginychannelswithvariablebifurcationanglesformicrofluidicapplications AT zaibali experimentalinvestigationofparticlesortinginychannelswithvariablebifurcationanglesformicrofluidicapplications AT msajid experimentalinvestigationofparticlesortinginychannelswithvariablebifurcationanglesformicrofluidicapplications |