TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study

TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study

Abstract Background In clinical practice, alterations in the internal environment of type 2 diabetes can significantly affect bone quality. While the increased risk of fractures among diabetic patients is well-established, the precise mechanisms by which hyperglycemia influences bone quality remain...

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Main Authors: Bo Peng, Zhiwei Feng, Ao Yang, Jinmin Liu, Jinwen He, Lihu Xu, Cong Tian, Xiaoyun Sheng, Yaobin Wang, Rongjin Chen, Xingwen Wang, Xiaojun Ren, Bin Geng, Yayi Xia
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
TIMP1
TFRC
Ubiquitination
Ferroptosis
Osteoblast
Iron metabolism
Online Access:https://doi.org/10.1186/s10020-024-01000-9
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https://doi.org/10.1186/s10020-024-01000-9

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