HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Abstract 4‐hydroxyphenylpyruvate dioxygenase (HPD) is an important metabolic enzyme in the tyrosine metabolic pathway and displays aberrant expression and function in cancer. Unexpectedly, it is discovered that HPD functions as an RNA‐binding protein (RBP) to drive ovarian cancer progression. HPD is...

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Main Authors: Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
4‐hydroxyphenylpyruvate dioxygenase (HPD)
glycolysis
mRNA translation
ovarian cancer
RNA‐binding protein
Online Access:https://doi.org/10.1002/advs.202503999
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https://doi.org/10.1002/advs.202503999

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