Mechanism of action and potential therapeutic targets of TGF-β-related signaling pathway and its downstream miRNA expression in pulmonary arterial hypertension

Pulmonary hypertension is a major cardiovascular disease characterized by the persistent elevation of pulmonary artery pressure, leading to vascular remodeling, fibrosis, and endothelial dysfunction. In recent years, the TGF-β signaling pathway and miRNAs have played important roles in the pathogene...

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Bibliographic Details
Main Authors: Yimo Huang, Wende Ma, Cen Guo, Xiaoling Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1596767/full
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