Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate

Methyl 6,7-Difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate

A convenient synthesis of a novel fluoroquinolone precursor, methyl 6,7-difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate, at a 78% yield starting from 3,4-difluorophenyl isothiocyanate was developed. The structure of the product was established by <sup>1</sup>H, <...

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Bibliographic Details
Main Authors: Vladimir A. Potapov, Irina A. Novokshonova, Maxim V. Musalov, Svetlana V. Amosova, Oleg A. Rakitin
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Molbank
Subjects:
fluoroquinolone derivative
3,4-difluorophenyl isothiocyanate
methyl 6,7-difluoro-2-[(4-fluorobenzyl)sulfanyl]-4-hydroxyquinoline-3-carboxylate
cyclization reaction
antibiotics
Online Access:https://www.mdpi.com/1422-8599/2024/4/M1889
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