Sex-dependent effects of FGF21 on HPA axis regulation and adrenal regeneration after Cushing syndrome in mice

Sex-dependent effects of FGF21 on HPA axis regulation and adrenal regeneration after Cushing syndrome in mice

Background: Cushing's syndrome (CS) results from prolonged exposure to excessive glucocorticoids (GCs), leading to metabolic disturbances and adrenal insufficiency (AI). Fibroblast growth factor 21 (FGF21) has shown promise as a potential therapeutic target for metabolic disorders. This study e...

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Main Authors: Daniela Díaz-Catalán, Júlia Capó, Arturo Vega-Beyhart, Maria Teresa Rodrigo-Calvo, Mireia Mora, Oscar Vidal, Mattia Squarcia, Joaquim Enseñat, Gregori Casals, Felicia Hanzu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
Adrenal insufficiency
Corticosterone
Fibroblast growth factor 21
Hypothalamic-pituitary-adrenal axis
Sex differences
Metabolic regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000298
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