Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection

Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection

Abstract Naturally circulating strains of eastern equine encephalitis virus (EEEV) bind heparan sulfate (HS) receptors and this interaction has been linked to neurovirulence. Previous studies associated EEEV-HS interactions with three positively charged amino acid clusters on the E2 glycoprotein. On...

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Main Authors: Maria D. H. Alcorn, Chengqun Sun, Theron C. Gilliland, Tetyana Lukash, Christine M. Crasto, Saravanan Raju, Michael S. Diamond, Scott C. Weaver, William B. Klimstra
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62513-3
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https://doi.org/10.1038/s41467-025-62513-3

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