An aggregation-induced conformation locking strategy facilitates the activation of lipase biocatalyst

Abstract Lipase represents one of the most important industrial biocatalysts, with a global market value of $590.5 million by 2020. However, their catalytic efficiency is often hindered by a closed “lid” conformation. Here, we present an aggregation-induced conformation locking strategy that enables...

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Bibliographic Details
Main Authors: Anlian Huang, Zhi-Wei Li, Lihong Guo, Ningyi Zhong, Linjing Tong, Yanbin Xu, Xiaomin Ma, Fang Zhu, Guosheng Chen, Siming Huang, Gangfeng Ouyang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59824-w
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