Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents.

Due to the use of morphine as a well-known analgesic, a semi-synthesis of its newer triazole derivatives was performed in this project. Several derivatives were analyzed via molecular docking and a set of target molecules with acceptable docking scores were selected for the synthesis. The project fo...

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Bibliographic Details
Main Authors: Faeze Nourmandipour, Reihane Emadi, Peyman Salehi, Mona Kamelan Zargar Zarin, Mona Khoramjouy, Amirreza Dowlati Beirami, Mehrdad Faizi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0323189
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