Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation

Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation

Abstract Accurate gametogenesis requires the establishment of the telomere bouquet, an evolutionarily conserved, 3D chromosomal arrangement. In this spatial configuration, telomeres temporarily aggregate at the nuclear envelope during meiotic prophase, which facilitates chromosome pairing and recomb...

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Main Authors: Alberto Jiménez-Martín, Alberto Pineda-Santaella, Rebeca Martín-García, Rodrigo Esteban-Villafañe, Alix Matarrese, Jesús Pinto-Cruz, Sergio Camacho-Cabañas, Daniel León-Periñán, Antonia Terrizzano, Rafael R. Daga, Sigurd Braun, Alfonso Fernández-Álvarez
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56049-9
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https://doi.org/10.1038/s41467-025-56049-9

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