Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression

Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression

Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. Among various hepatic genes impacted during MASLD development, CYP7B1 is consistently suppresse...

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Main Authors: Genta Kakiyama, Nanah Bai-Kamara, Daniel Rodriguez-Agudo, Hajime Takei, Kei Minowa, Michael Fuchs, Sudha Biddinger, Jolene J. Windle, Mark A. Subler, Tsuyoshi Murai, Mitsuyoshi Suzuki, Hiroshi Nittono, Arun Sanyal, William M. Pandak
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Lipid Research
Subjects:
CD36
cholesterol
inflammation
liver
lipotoxicity
oxysterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000173
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