Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach

Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach

In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority. To identify potential sepsis drug candidates, we used an optimized larval zebrafish model of endotoxicity/sepsis to...

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Bibliographic Details
Main Authors: Mark Widder, Chance Carbaugh, William van der Schalie, Ronald Miller, Linda Brennan, Ashley Moore, Robert Campbell, Kevin Akers, Roseanne Ressner, Monica Martin, Michael Madejczyk, Blair Dancy, Patricia Lee, Charlotte Lanteri
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Life
Subjects:
sepsis
endotoxicity
drug discovery
zebrafish
lipopolysaccharide
Online Access:https://www.mdpi.com/2075-1729/14/12/1689
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https://www.mdpi.com/2075-1729/14/12/1689

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