Terconazole loaded edge-activated hybrid elastosome for revamped corneal permeation in ocular mycosis: In-vitro characterization, statistical optimization, microbiological assessment, and in-vivo evaluation.

Terconazole loaded edge-activated hybrid elastosome for revamped corneal permeation in ocular mycosis: In-vitro characterization, statistical optimization, microbiological assessment, and in-vivo evaluation.

Herein, we investigated the preparation and characterization of Terconazole loaded edge-activated hybrid elastosome (TCN-EHE) adopting thin film hydration technique for the treatment of ocular mycosis. Terconazole (TCN) is a broad spectrum antimycotic agent suffering from sparse aqueous solubility i...

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Bibliographic Details
Main Authors: Sadek Ahmed, Michael M. Farag, Heba Attia, Bander Balkhi, Islam M. Adel, Asmaa Ashraf Nemr
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Journal of Pharmaceutics: X
Subjects:
Terconazole
Hybrid elastosome
Edge activator
Ocular mycosis
Biofilm inhibition
Corneal permeation
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156725000180
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