Cryo-EM structure of the β-1,3-glucan synthase FKS1-Rho1 complex

Cryo-EM structure of the β-1,3-glucan synthase FKS1-Rho1 complex

Abstract β-1,3 Glucan synthase (GS) is essential for fungal cell wall biosynthesis. The GS holoenzyme comprises the glycosyltransferase FKS1 and its regulatory factor Rho1, a small GTPase. However, the mechanism by which Rho1 activates FKS1 in a GTP-dependent manner remains unclear. Here, we present...

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Main Authors: Jialu Li, Huayi Liu, Jian Li, Juxiu Liu, Xinli Dai, Angqi Zhu, Qingjie Xiao, Wenyu Qian, Honghao Li, Li Guo, Chuangye Yan, Dong Deng, Yunzi Luo, Xiang Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57152-7
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https://doi.org/10.1038/s41467-025-57152-7

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