Role of the NO-GC/cGMP signaling pathway in platelet biomechanics

Role of the NO-GC/cGMP signaling pathway in platelet biomechanics

Cyclic guanosine monophosphate (cGMP) is a second messenger produced by the NO-sensitive guanylyl cyclase (NO-GC). The NO-GC/cGMP pathway in platelets has been extensively studied. However, its role in regulating the biomechanical properties of platelets has not yet been addressed and remains unknow...

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Main Authors: Aylin Balmes, Johanna G. Rodríguez, Jan Seifert, Daniel Pinto-Quintero, Akif A. Khawaja, Marta Boffito, Maike Frye, Andreas Friebe, Michael Emerson, Francesca Seta, Robert Feil, Susanne Feil, Tilman E. Schäffer
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Platelets
Subjects:
Cellular stiffness
cyclic guanosine monophosphate (cGMP)
inhibition of platelet activation
NO-sensitive guanylyl cyclase (NO-GC) enzyme
platelet shape
Online Access:https://www.tandfonline.com/doi/10.1080/09537104.2024.2313359
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https://www.tandfonline.com/doi/10.1080/09537104.2024.2313359

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