Evolutionary regulation of human Fas ligand (CD95L) by plasmin in solid cancer immunotherapy

Abstract Despite sharing >98% genomic similarity, humans are more likely to develop cancers than our closest living ancestors, the nonhuman primates. Here, we unexpectedly discover that, unlike chimpanzee and other primates, a critical embryonic development, immune homeostasis, and general cell-d...

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Bibliographic Details
Main Authors: Brice E. N. Wamba, Tanmoy Mondal, Francis Freenor V, Mehr Shaheed, Oliver Pang, Daniel Bedinger, Patrick Legembre, Laurent Devel, Sanchita Bhatnagar, Gary Scott Leiserowitz, Jogender Tushir-Singh
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60990-0
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