Anticonvulsant Profiles of Three Hemorphin-4 Analogs with Rhodamine B in Mice

Anticonvulsant Profiles of Three Hemorphin-4 Analogs with Rhodamine B in Mice

<b>Background/Objectives</b>: Hemorphins, considered to be bioactive atypical oligopeptides, are products of hemoglobin metabolism. Recently, our team reported the synthesis and characterization of three N-modified analogs of hemorphin-4 (H4) with rhodamine B (Rh). In the present study,...

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Bibliographic Details
Main Authors: Jana Tchekalarova, Miroslav Rangelov, Ivan Iliev, Nadezhda Todorova, Tsveta Stoyanova, Lian Nedelchev, Petar Todorov
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
hemorphin
seizure test
PTZ kindling
cytotoxicity and phototoxicity
docking analysis
mice
Online Access:https://www.mdpi.com/1424-8247/18/5/673
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