Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Abstract Atherosclerosis has an urgent need for new therapeutic targets. Protein kinases orchestrate multiple cellular events in atherosclerosis and may provide new therapeutic targets for atherosclerosis. Here, a protein kinase, WEE1 G2 checkpoint kinase (WEE1), promoting inflammation in atheroscle...

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Main Authors: Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
atherosclerosis
inflammation
macrophage
NF‐κB p65
WEE1
Online Access:https://doi.org/10.1002/advs.202503192
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https://doi.org/10.1002/advs.202503192

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