Correlation between UGT1A1 polymorphism and efficacy and toxicity of irinotecan in Chinese cancer patients

Correlation between UGT1A1 polymorphism and efficacy and toxicity of irinotecan in Chinese cancer patients

ObjectiveTo assess the association between UGT1A1*6/*28 polymorphisms and Irinotecan (IRI) efficacy/toxicity in Chinese cancer patients.MethodWe systematically searched PubMed, Cochrane, CNKI, and Wanfang databases. Two investigators independently conducted literature screening, data extraction, and...

Full description

Saved in:
Bibliographic Details
Main Authors: Shuai Geng, Yulong Shen, Chen Zhang, Nan Wang, Xinyue Gao, Xinyu Luo, Ning Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
gene polymorphism
UGT1A1∗6
UGT1A1∗28
irinotecan
efficacy
toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1563566/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2025.1563566/full

Similar Items