Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies

Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies

Type 2 diabetes mellitus (T2DM) is an intricate disease correlated with many metabolic deregulations, including disordered glucose metabolism, oxidative stress, inflammation, and cellular apoptosis due to hepatic gluconeogenesis aberrations. However, there is no radical therapy to inhibit hepatic gl...

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Bibliographic Details
Main Authors: Heba M. Abdou, Ghada M. Abd Elmageed, Hussein K. Hussein, Imane Yamari, Samir Chtita, Lamia M. El-Samad, Mohamed A. Hassan
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Journal of Xenobiotics
Subjects:
type 2 diabetes mellitus
quercetin
silk sericin
hepatic gluconeogenesis
caspase-3
PI3K/Akt/FOXO1 signal
Online Access:https://www.mdpi.com/2039-4713/15/1/16
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