VP3.15, a dual GSK-3β/PDE7 inhibitor, reduces glioblastoma tumor growth though changes in the tumor microenvironment in a PTEN wild-type context

VP3.15, a dual GSK-3β/PDE7 inhibitor, reduces glioblastoma tumor growth though changes in the tumor microenvironment in a PTEN wild-type context

Glioblastoma (GB) is an incurable cancer of the brain, and there is an urgent need to identify effective treatments. This may be achieved by either identifying new molecules or through drug repurposing. To ascertain the therapeutic potential of known GSK-3β and/or PDE7 inhibitors in GB, a drug scree...

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Bibliographic Details
Main Authors: Maria Castello-Pons, Maria A. Ramirez-Gonzalez, Patricia Iglesias-Hernández, Nermina Logo Lendo, Carlos Rodriguez-Martín, Laura Quiralte, Juan-Manuel Sepúlveda-Sánchez, Olaya de Dios, Carmen Gil, Ana Martínez, Pilar Sánchez-Gómez, Sergio Casas-Tinto
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neurotherapeutics
Subjects:
GSK-3β
PDE7A
PTEN
GAL9
Tumor microenvironment
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747925000546
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http://www.sciencedirect.com/science/article/pii/S1878747925000546

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