GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells

GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells

Despite their genetic diversity, metastatic cells converge on similar physical constraints during tumor progression. At the nanoscale, these forces can induce substantial molecular deformations, altering the structure and behavior of cancer cells. To address the challenges of osteosarcoma (OS), a hi...

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Bibliographic Details
Main Authors: Arianna Buglione, Giulia Alloisio, Chiara Ciaccio, David Becerril Rodriguez, Simone Dogali, Marco Luce, Stefano Marini, Antonio Cricenti, Magda Gioia
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:European Journal of Cell Biology
Subjects:
Mechanobiology
Osteosarcoma
Cyclic uniaxial stretch
Mechanosensitive ion channels
Grammostola mechanoToxin 4 (GsMTx-4)
Doxorubicin sensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933524000864
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