An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy

An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy

Abstract T cell receptor (TCR) based immunotherapy is an attractive strategy to target a wide range of intra‐tumoral antigens and elicit robust tumor cytotoxicity. However, engineering soluble TCR engagers that preserve physiological affinity is crucial for universal TCR drug development, yet remain...

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Main Authors: Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W.H. Zhang, Xiaopeng Ma, Hui Tan, George F. Gao, Shuguang Tan
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
fine‐tuned TCR affinity
KRAS‐G12V mutation
TCR engagers
tumor inhibition
Online Access:https://doi.org/10.1002/advs.202500181
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https://doi.org/10.1002/advs.202500181

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