Intestinal Lymphatic Delivery of Praziquantel by Solid Lipid Nanoparticles: Formulation Design, In Vitro and In Vivo Studies

The aim of the present work was to design and develop Praziquantal (PZQ) loaded solid lipid nanoparticles (PZQ-SLN) to improve the oral bioavailability by targeting intestinal lymphatic system. PZQ is practically insoluble in water and exhibits extensive hepatic first-pass metabolism. PZQ SLN were c...

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Bibliographic Details
Main Authors: Amit Mishra, Parameswara Rao Vuddanda, Sanjay Singh
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Journal of Nanotechnology
Online Access:http://dx.doi.org/10.1155/2014/351693
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