NK cell-derived artificial extracellular vesicles elicit potent anti-tumor efficacy and tumor microenvironment reprogramming capability

NK cell-derived artificial extracellular vesicles elicit potent anti-tumor efficacy and tumor microenvironment reprogramming capability

Abstract Natural Killer cell-derived extracellular vesicles (NK–EVs) hold promise for cancer immunotherapy but face limitations in yield and efficacy. This study developed artificial NK–EVs (NK–aEVs) via extrusion, demonstrating superior scalability and bioactivity compared to natural EVs (NK–nEVs),...

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Bibliographic Details
Main Authors: Xinyue Zhou, Hang Yuan, Xinyue Zhu, Yangli Liu, Jinmin Xiao, Xueting Xie, Linlin Che, Cheng Fang, Chao Yao, Dan Hu, Yufu Zhou, Lixin Wang, Chenyuan Gong, Shiguo Zhu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Nanotechnology
Subjects:
NK cells
Artificial extracellular vesicles
Tumor immunotherapy
Online Access:https://doi.org/10.1186/s12645-025-00328-z
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https://doi.org/10.1186/s12645-025-00328-z

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