Neoadjuvant chemoradiotherapy with or without PD-1/PD-L1 inhibitors in locally advanced rectal cancer: a systematic review and meta-analysis

Neoadjuvant chemoradiotherapy with or without PD-1/PD-L1 inhibitors in locally advanced rectal cancer: a systematic review and meta-analysis

Abstract Background Locally advanced rectal cancer (LARC) represents a pivotal stage of rectal cancer where it is possible to completely cure the cancer before its systemic spread, thus often requiring an aggressive multimodal therapy. Recent trials suggest that programmed cell death protein 1 (PD-1...

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Main Authors: Muhammad Ansab, Sepideh Razi, Farwa Nisa, Eiman Araib, Shree Rath, Iqra Khan, Noor Ul Huda Ramzan, Esha Dilawar, Anwaar Saeed
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Locally advanced rectal cancer
PD-1 inhibitors
Neoadjuvant chemoradiotherapy
Pathological complete response
Immunotherapy
Clinical complete response
Online Access:https://doi.org/10.1186/s12885-025-14482-5
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https://doi.org/10.1186/s12885-025-14482-5

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