Spontaneous tumor regression and immunotherapy response demonstrate clonal T-cell expansion in Merkel cell carcinoma

Spontaneous tumor regression and immunotherapy response demonstrate clonal T-cell expansion in Merkel cell carcinoma

Abstract Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is responsive to immune checkpoint inhibitors (ICI). On rare occasion, MCC spontaneously regresses. It is speculated that this regression occurs when biopsy-induced antigen shedding precipitates an immune r...

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Main Authors: Patrick Hallaert, John W. Roman, Mairead Baker, Natasha T. Hill, Jennifer L. Marte, James L. Gulley, Nicholas Logemann, Courtney W. Hudgens, Alexandre Reuben, Isaac Brownell
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00987-6
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https://doi.org/10.1038/s41698-025-00987-6

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