Dysregulation of cell migration by matrix metalloproteinases in geleophysic dysplasia

Dysregulation of cell migration by matrix metalloproteinases in geleophysic dysplasia

Abstract Geleophysic dysplasia (GD) is characterized by short stature, brachydactyly, joint limitations, a distinctive facial appearance, as well as cardiac and respiratory dysfunction that can be life-threatening. GD is caused by pathogenic variants in the ADAMTSL2, FBN1, or LTBP3 genes. While derm...

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Bibliographic Details
Main Authors: Alejo A. Morales, Vladimir Camarena, LéShon Peart, Sarah Smithson, Lindsay Shaw, Lucy Webber, Jose M. Negron, Juan E. Sola, Ann-Christina Brady, Katherina Walz, Gaofeng Wang, Mustafa Tekin
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Geleophysic dysplasia
ADAMTSL2
FBN1
MMPs
MMP-1
MMP-14
Online Access:https://doi.org/10.1038/s41598-025-04666-1
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https://doi.org/10.1038/s41598-025-04666-1

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