Therapeutic targeting of protein arginine methyltransferases reduces breast cancer progression by disrupting angiogenic pathways

Therapeutic targeting of protein arginine methyltransferases reduces breast cancer progression by disrupting angiogenic pathways

Protein arginine methylation is an epigenetic modification involved in transcription, splicing and signal transduction and is mediated by protein arginine methyltransferases (PRMTs). PRMTs regulate various tumor angiogenesis pathways, including vascular endothelial growth factor receptor-2 (VEGFR-2)...

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Bibliographic Details
Main Authors: Kamohelo Maphalala, Dakalo Portia Ramali, Lorraine Tshegofatso Maebele, Thanyani Victor Mulaudzi, Peace Mabeta, Zodwa Dlamini, Botle Precious Damane
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Breast cancer
Angiogenesis
Angiogenic signaling pathways
Hypoxia
Vascularization
Protein arginine methyltransferase inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825002596
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