Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits

Genome-wide association study of plasma amino acids and Mendelian randomization for cardiometabolic traits

Abstract Plasma amino acids (AAs) have emerged as promising biomarkers for metabolic disorders, yet their causality remains unclear. We aimed to investigate the genetic determinants of AA levels in a cohort of 10,333 individuals and their causal effects on cardiometabolic traits using Mendelian rand...

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Main Authors: Ryota Toki, Sotaro Fushiki, Shun Kojima, Yoichi Sutoh, Yayoi Otsuka-Yamasaki, Sei Harada, Miho Iida, Aya Hirata, Naoko Miyagawa, Minako Matsumoto, Shun Edagawa, Atsuko Miyake, Kazuyo Kuwabara, Akiyoshi Hirayama, Masahiro Sugimoto, Asako Sato, Kaori Amano, Tomoyoshi Soga, Masaru Tomita, Kazuharu Arakawa, Kengo Kinoshita, Mika Sakurai-Yageta, Gen Tamiya, Hideki Ohmomo, Atsushi Shimizu, Tomonori Okamura, Toru Takebayashi
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Amino acids
Cardiometabolic diseases
Genome-wide association study
Mendelian randomization
Metabolomics
Online Access:https://doi.org/10.1038/s41598-025-98992-z
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https://doi.org/10.1038/s41598-025-98992-z

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