Synthesis of 1,2,4-Oxadiazin-5(6<i>H</i>)-One Derivatives and Their Biological Investigation as Monoamine Oxidase Inhibitors

Synthesis of 1,2,4-Oxadiazin-5(6<i>H</i>)-One Derivatives and Their Biological Investigation as Monoamine Oxidase Inhibitors

Monoamine oxidase (MAO) plays a key role in the pathogenesis of central nervous system disorders, and MAO inhibitors have been used in the treatment of depression and Parkinson’s disease. In the search for new classes of MAO inhibitors, the present study investigated a series of 1,2,4-oxadiazin-5(6&...

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Main Authors: Sofia I. Presnukhina, Valentina D. Kotlyarova, Anton A. Shetnev, Sergey V. Baykov, Rakhymzhan Turmanov, Nurbol Appazov, Rakhmetulla Zhapparbergenov, Leilya Zhussupova, Nurila Togyzbayeva, Stephanus J. Cloete, Mikhail K. Korsakov, Vadim P. Boyarskiy, Anél Petzer, Jacobus P. Petzer
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
monoamine oxidase
MAO
oxadiazine
inhibition
Parkinson’s disease
Online Access:https://www.mdpi.com/1420-3049/29/23/5550
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