Interspecies transcriptome profiles of human T cell activation and liver inflammation in a xenogeneic graft-versus-host disease model

Interspecies transcriptome profiles of human T cell activation and liver inflammation in a xenogeneic graft-versus-host disease model

Background: Xenogeneic transplantation induces acute graft-versus-host disease (aGvHD) and subsequent vital organ damage. Herein, we aimed to examine hepatic damage associated with aGvHD using histopathology and gene expression profiles. Methods: A xenografic GvHD model was established by engrafting...

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Bibliographic Details
Main Authors: Seo Yule Jeong, Duhyeon Park, Tamina Park, Ji-Seok Han, Jungyun Lee, Chang Hoon Choi, Minseong Jo, Yu Bin Lee, Mi-lang Kyun, Myeongjin Choi, Daeui Park, Kyoung-Sik Moon
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Graft-versus-host disease
Humanized mouse model
T cell pathway
Liver toxicity
Transcriptome analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024165905
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http://www.sciencedirect.com/science/article/pii/S2405844024165905

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