NADPH Oxidase 4: Crucial for Endothelial Function under Hypoxia—Complementing Prostacyclin

NADPH Oxidase 4: Crucial for Endothelial Function under Hypoxia—Complementing Prostacyclin

<i>Aim</i>: The primary endothelial NADPH oxidase isoform 4 (NOX4) is notably induced during hypoxia, with emerging evidence suggesting its vasoprotective role through H<sub>2</sub>O<sub>2</sub> production. Therefore, we aimed to elucidate NOX4′s significance in e...

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Bibliographic Details
Main Authors: Heike Brendel, Jennifer Mittag, Anja Hofmann, Helene Hempel, Sindy Giebe, Patrick Diaba-Nuhoho, Steffen Wolk, Christian Reeps, Henning Morawietz, Coy Brunssen
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Antioxidants
Subjects:
NADPH oxidase 4
hypoxia
PTGIS
endothelial function
human endothelial cells
laminar flow
Online Access:https://www.mdpi.com/2076-3921/13/10/1178
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