Identification and characterization of GLDC as host susceptibility gene to severe influenza

Identification and characterization of GLDC as host susceptibility gene to severe influenza

Abstract Glycine decarboxylase (GLDC) was prioritized as a candidate susceptibility gene to severe influenza in humans. The higher expression of GLDC derived from genetic variations may confer a higher risk to H7N9 and severe H1N1 infection. We sought to characterize GLDC as functional susceptibilit...

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Main Authors: Jie Zhou, Dong Wang, Bosco Ho‐Yin Wong, Cun Li, Vincent Kwok‐Man Poon, Lei Wen, Xiaoyu Zhao, Man Chun Chiu, Xiaojuan Liu, Ziwei Ye, Shuofeng Yuan, Kong‐Hung Sze, Jasper Fuk‐Woo Chan, Hin Chu, Kelvin Kai‐Wang To, Kwok Yung Yuen
Format: Article
Language:English
Published: Springer Nature 2018-11-01
Series:EMBO Molecular Medicine
Subjects:
antiviral response
genetic susceptibility
GLDC
severe influenza
viral replication
Online Access:https://doi.org/10.15252/emmm.201809528
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https://doi.org/10.15252/emmm.201809528

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