Alteration in ATR protein level does not account for the inherent radiosensitivity of HPV-positive head and neck squamous cell carcinoma

Alteration in ATR protein level does not account for the inherent radiosensitivity of HPV-positive head and neck squamous cell carcinoma

Objectives: Human papilloma virus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) cells are highly radiosensitive resulting from an elevated number of DNA double-strand breaks (DSB) remaining after irradiation. Partially this effect is due to a defective homologous recombination (HR). H...

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Bibliographic Details
Main Authors: Sibylla Kohl, Florentine S.B. Subtil, Vanessa Climenti, Houmam Anees, Ann C. Parplys, Rita Engenhart-Cabillic, Sebastian Adeberg, Ekkehard Dikomey, Ulrike Theiß
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Translational Oncology
Subjects:
Head and neck squamous cell carcinoma
Human papilloma virus
ATR
Radiosensitivity
DSB repair
HR
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325000907
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