Mapping of RORγt+ dendritic cells in human tissues establishes their preferential niche in adult lymph nodes

Mapping of RORγt+ dendritic cells in human tissues establishes their preferential niche in adult lymph nodes

BackgroundThe retinoic-acid-receptor-related orphan receptor gamma t (RORγt) isoform is required for the development of lymphoid organs, T-helper 17 cells (Th17), and innate lymphoid cells (ILC3s). Recent data in mouse and human have revealed non-T, non-ILC3 cell populations with antigen presenting...

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Main Authors: Silvia Lonardi, Francisco MA Bianchetto-Aguilera, Matilde Monti, Anna Di Matteo, Francesco Missale, Sara Picinoli, Mattia Bugatti, Martina Benedetti, Giorgia Ferrari, Marco A. Cassatella, Daniele Moratto, Stefania Zini, Valentina Agostini, Viola Savoldi, Luisa Lorenzi, Marco Chiarini, Fabio Facchetti, Shitong Wu, Alina Ulezko Antonova, Yizhou A. Liu, Marina Cella, Claudia Ghigna, Marco Colonna, William Vermi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
RORγt
RORC2
dendritic cells
lymph nodes
lymphoid organs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527499/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1527499/full

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