Evaluation of a simplified radiolabeling method for a PARP inhibitor in an animal model of breast cancer

Evaluation of a simplified radiolabeling method for a PARP inhibitor in an animal model of breast cancer

Abstract Background Several poly (adenosine diphosphate–ribose) polymerase (PARP) inhibitors were recently approved by the US Food and Drug Administration for use in cancer treatment. To facilitate the discovery of novel PARP-targeting ligands, a radioiodinated ligand, I-125-KX1, was developed and v...

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Main Authors: Chi-Chang Weng, Chao-Chih Chiang, Yi-Hsiu Chung, Yi-Pei Ho, Yu-Chuan Chang, Ing-Tsung Hsiao, Robert H. Mach
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:EJNMMI Research
Subjects:
PARP
I-123/125-KX1
SPE
Breast cancer
Saturation binding assay
In vitro autoradiography
Online Access:https://doi.org/10.1186/s13550-025-01236-4
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https://doi.org/10.1186/s13550-025-01236-4

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