Reducing Systemic Inflammation in IUGR-Born Neonatal Lambs via Daily Oral ω-3 PUFA Supplement Improved Skeletal Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Blood Pressure

Reducing Systemic Inflammation in IUGR-Born Neonatal Lambs via Daily Oral ω-3 PUFA Supplement Improved Skeletal Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Blood Pressure

Background/Objectives: Intrauterine growth restriction (IUGR) is associated with enhanced inflammatory activity, poor skeletal muscle glucose metabolism, and pancreatic β cell dysfunction that persist in offspring. We hypothesized that targeting heightened inflammation in IUGR-born neonatal lambs by...

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Bibliographic Details
Main Authors: Melanie R. White, Rachel L. Gibbs, Pablo C. Grijalva, Zena M. Hicks, Haley N. Beer, Eileen S. Marks-Nelson, Dustin T. Yates
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
Subjects:
adaptive fetal programming
developmental origins of health and disease (DOHaD)
glucose homeostasis
low birthweight
maternofetal health
omega-3 polyunsaturated fatty acid (ω-3 PUFA)
Online Access:https://www.mdpi.com/2218-1989/15/6/346
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