7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B

7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline. 7-α-O-Methylmorroniside (MorA), an iridoid glycoside extracted from Cornus officinalis Sieb. et Zucc., has been shown to have neuroprotective effects, but the mechanism of its anti-AD effect has not been cla...

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Bibliographic Details
Main Authors: Fengxiao Hao, Mengnan Zeng, Bing Cao, Xiwen Liang, Zhiyou Hao, Kaili Ye, Xinmian Jiao, Weisheng Feng, Xiaoke Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
5×FAD mice
7-α-O-Methylmorroniside
gut microbiome
NMDAR2B
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1545566/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1545566/full

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