Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants

Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants

Abstract The effectiveness of intramuscular vaccines aimed at preventing severe COVID-19 remains limited due to waning immunity and the emergence of novel variants. Next-generation vaccines are needed for broader protection and blocking virus transmission. Here, we rationally designed an original na...

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Main Authors: Zineb Lakhrif, Agathe Poupée-Beaugé, Fanny Boursin, Céline Ducournau, Louis Lantier, Nathalie Moiré, Rodolphe Carpentier, Christelle Rossignol, Marianne Maquart, Fabienne Jospin, Laetitia Merat, Mireille Caul-Futy, Yazdan Yazdanpanah, Amel Bouakane, Mickael Riou, Antoine Touzé, Jean-François Eléouët, Charles-Adrien Richard, François Helle, Sophie Le Poder, Bernard Klonjkowski, Nicolas Meunier, Stéphan Zientara, Stéphane Paul, Marie-Noëlle Mévélec, Nicolas Aubrey, Mathieu Epardaud, Isabelle Dimier-Poisson
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01123-y
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https://doi.org/10.1038/s41541-025-01123-y

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