α-酮戊二酸介导异柠檬酸脱氢酶3A发挥抑制心肌细胞肥大的作用
目的探究异柠檬酸脱氢酶3A(IDH3A)对心肌细胞肥大的调控作用和潜在机制。方法通过实时荧光定量PCR(RT-qPCR)和Western blot实验检测健康志愿者(<italic>n</italic>=10)与心力衰竭患者(<italic>n</italic>=10)心肌组织标本、假手术组与主动脉弓缩窄术(TAC)小鼠心肌标本以及去氧肾上腺素(PE)诱导的乳大鼠心肌细胞(NRVCs)中IDH3A的表达水平。利用腺病毒介导在PE诱导的NRVCs中过表达IDH3A,检测其对NRVCs肥厚相关基因表达的影响,并通过鬼笔环肽染色检测IDH3A对NRVC...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Sun Yat-sen University
2025-03-01
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| Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
| Subjects: | |
| Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0211/ |
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