Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer’s disease and Parkinson’s disease

Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer’s disease and Parkinson’s disease

Abstract Background Synaptic dysfunction is a relevant feature of Alzheimer’s disease (AD) and Parkinson’s disease (PD) and can be quantified through the measurement of cerebrospinal fluid (CSF) synaptic markers, such as the presynaptic proteins synaptosomal-associated protein 25 kDa (SNAP25) and ve...

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Main Authors: Lorenzo Gaetani, Giovanni Bellomo, Davide Chiasserini, Charlotte De Rocker, Julie Goossens, Federico Paolini Paoletti, Eugeen Vanmechelen, Lucilla Parnetti
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Parkinson’s disease
Synaptic markers
SNAP25
VAMP2
Cerebrospinal fluid
Online Access:https://doi.org/10.1186/s13195-025-01762-2
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https://doi.org/10.1186/s13195-025-01762-2

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