Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation

Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation

BackgroundMetabolic dysregulation in metabolic syndrome (MetS) exacerbates myocardial ischemia-reperfusion injury (MIRI). This study aimed to identify diagnostic biomarkers and therapeutic candidates for MetS-associated MIRI.MethodsThree MIRI and two MetS datasets from GEO were analyzed using differ...

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Bibliographic Details
Main Authors: Shufang Liu, Yan Zhang, Yanan Zhao, Ping Wu, Shouyuan Tian, Han-Qing Pang, Zhifang Wu, Sijin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
myocardial ischemia reperfusion injury
metabolic syndrome
machine learning
molecular docking
immune infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567572/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567572/full

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