Ecteinascidin synthetic analogues: a new class of selective inhibitors of transcription, exerting immunogenic cell death in refractory malignant pleural mesothelioma

Ecteinascidin synthetic analogues: a new class of selective inhibitors of transcription, exerting immunogenic cell death in refractory malignant pleural mesothelioma

Abstract Background Malignant pleural mesothelioma (MPM) is a highly chemo-refractory and immune-evasive tumor that presents a median overall survival of 12–14 months when treated with chemotherapy and immunotherapy. New anti-tumor therapies as well as the concomitant reactivation of immune destruct...

Full description

Saved in:
Bibliographic Details
Main Authors: I. C. Salaroglio, P. Aviles, J. Kopecka, A. Merlini, F. Napoli, L. Righi, S. Novello, H. Sullivan, C. Cuevas, G. V. Scagliotti, C. Riganti
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Malignant pleural mesothelioma
Ecteinascidins
DNA damage
Immunogenic cell death
cGAS/STING pathway
Chemo-immunotherapy
Online Access:https://doi.org/10.1186/s13046-024-03253-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13046-024-03253-y

Similar Items