Pro-repair macrophages driven by CGRP rescue white matter integrity following intracerebral hemorrhage

Pro-repair macrophages driven by CGRP rescue white matter integrity following intracerebral hemorrhage

Abstract Background Intracerebral hemorrhage (ICH) triggers a dynamic immune response involving macrophages, However, the functional heterogeneity of these cells and the mechanisms through which they promote repair remain unclear. Although the neuropeptide CGRP has been shown to modulate macrophage...

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Main Authors: Huaping Huang, Yirui Kuang, Yang Chen, Yi Zhang, Jiayin Zhou, Xian Yu, Yonghe Zheng, Lingxin Cai, Wanglu Hu, Liansheng Gao, Haijian WU, Hui Ling, Xiao Dong, Hang Zhou, Xiaobo Yu, Yucong Peng, Gao Chen, Xiaoyu Wang, Wei Yan
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Neuroinflammation
Subjects:
Intracerebral hemorrhage (ICH)
Macrophage
Calcitonin gene-related peptide (CGRP)
THBS1
Neuroimmune axis
White matter repair
Online Access:https://doi.org/10.1186/s12974-025-03483-7
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https://doi.org/10.1186/s12974-025-03483-7

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