Sarcopenic obesity is attenuated by E-syt1 inhibition via improving skeletal muscle mitochondrial function

Sarcopenic obesity is attenuated by E-syt1 inhibition via improving skeletal muscle mitochondrial function

In aging and metabolic disease, sarcopenic obesity (SO) correlates with intramuscular adipose tissue (IMAT). Using bioinformatics analysis, we found a potential target protein Extended Synaptotagmin 1 (E-syt1) in SO. To investigate the regulatory role of E-syt1 in muscle metabolism, we performed in...

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Main Authors: Chao Song, Wu Zheng, Guoming Liu, Yiyang Xu, Zhibo Deng, Yu Xiu, Rongsheng Zhang, Linhai Yang, Yifei Zhang, Guoyu Yu, Yibin Su, Jun Luo, Bingwei He, Jie Xu, Hanhao Dai
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
Sarcopenic obesity
E-syt1
Myogenesis
Mitochondria
Mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004452
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